Abnormal Function of the Vasopressin-cyclic-AMP-aquaporin2 Axis During Urine Concentrating and Diluting in Patients with Reduced Renal Function. A Case Control Study

Erling B Pedersen; Ingrid M Thomsen; Thomas G Lauridsen


BMC Nephrology. 2010;11(26) 

In This Article



Healthy Control Subjects Sixteen healthy subjects were recruited. Six subjects were excluded, five due to abnormal 24 hours ambulatory blood pressure measurement and one due to incorrect urine collection. Thus, ten subjects fulfilled the study (Group 1), five women and five men, with a median age of 41 years (range 30–54 years), a median body mass index of 23 (range 20–27) and a median e-GFR of 108 ml/min/kg (range 93–142 ml/min/kg).

Patients Forty-one patients were included and fulfilled the study. The patients were classified in three groups according to e-GFR (Groups 2–4). Group 2 (n = 14) comprised 6 women and 8 men, with a median age of 49 years (range 30–58 years), a median body mass index of 26 (range 20–35) and a median e-GFR of 99 ml/min/70 kg (range 90–140 ml/min/70 kg). Group 3 (n = 11) comprised 1 woman and 10 men with a median age of 53 years (range 39–71 years), a median body mass index of 26 (range 23–34) and a median e-GFR of 79 ml/min/70 kg (range 65–89 ml/min/70 kg). Group 4 (n = 16) comprised 4 women and 12 men with a median age of 59 years (range 37–73 years), a median body mass index of 27 (range 22–32) and a median e-GFR of 25 ml/min/70 kg (range 12–56 ml/min/70 kg).

The primary renal disease was nephrosclerosis (n = 11), chronic glomerulonephritis (n = 7), adult polycystic kidney disease (n = 3), interstitial nephropathy (n = 1), and unknown nephropathy (n = 19). All patients received antihypertensive treatment in various combinations, i.e.loop diuretics (n = 11), calcium channel antagonists (n = 14), thiazides (n = 15), angiotensin converting enzyme inhibitors (n = 16), angiotensin II receptor antagonists (n = 16), β-adrenergic blockers (n = 16), α-adrenergic blockers (n = 3), and α-calcidol (n = 4).

We did not see any deterioration in renal function either during urine concentrating or diluting test.


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