Gut Inflammation in Chronic Fatigue Syndrome

Shaheen E Lakhan; Annette Kirchgessner


Nutr Metab. 2010;7(1) 

In This Article


Clearly, much work remains in terms of understanding the role of gut inflammation in CFS development. Despite several studies showing health benefits of probiotics, the enthusiasm for their application as well as other means to alter the intestinal microbial ecosystem in the prevention of CFS needs to be tempered due to the current lack of knowledge of the normal gut microbiota, in addition to questions as to how it affects the immune system. Future studies using newly developed techniques to evaluate the gut microbiota in CFS patients and/or animal models of CFS are certainly needed. In addition, research on the effects of mucosal barrier dysfunction on enteric nerves and their activity in CFS are clearly warranted.


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