Novel Therapeutic Approaches for Inclusion Body Myositis

Thomas E. Lloyd

Disclosures

Curr Opin Rheumatol. 2010;22(6):658-664. 

In This Article

Strategies to Slow Muscle Degeneration

Although stimulating muscle regeneration shows promise in improving muscle strength in myositis patients, it does not address the underlying disease pathogenesis. In fact, in some patients, autoantibodies may recognize antigens that are enriched in regenerating fibers,[26] making it possible that enhancing regeneration without suppressing inflammation could actually be counter-productive. In patients with immunotherapy-refractory myositis, such as sIBM, addressing the underlying pathogenic process is critical. Even in patients with immune-mediated myositis, there are clearly nonimmune mechanisms that cause muscle degeneration (reviewed in [2]).

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....