Novel Therapeutic Approaches for Inclusion Body Myositis

Thomas E. Lloyd


Curr Opin Rheumatol. 2010;22(6):658-664. 

In This Article

Strategies to Accelerate Muscle Growth

In theory, therapies that enhance muscle regeneration could be beneficial in all muscle diseases regardless of cause. For this reason, intense research has been undertaken to develop drugs that stimulate myofiber regeneration in addition to cell-mediated therapies to replace injured myofibers. Androgens to stimulate muscle hypertrophy have long been used by body builders, but their use in patients is limited due to side-effects. Oxandrolone is a synthetic testosterone analog that is well tolerated in patients, and has shown efficacy in a small, double-blinded placebo-controlled trial in IBM.[4] Research over the last decade has implicated the myostatin pathway as a central regulator of myogenesis during development. More recently, inhibition of the myostatin pathway has shown great promise in enhancing muscle regeneration in animal models of muscle diseases.


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