Potential Markers for Chronic Allograft Dysfunction

Ron Shapiro, MD


November 22, 2010

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Hi, my name is Ron Shapiro. I'm a transplant surgeon at the University of Pittsburgh. Today I want to talk to you about an interesting paper from Amsterdam looking at protocol biopsies.[1] The protocol biopsies at 6 months that had a high amount of vimentin and CD44 in the renal tubules were associated with the development of interstitial fibrosis and tubular atrophy at the 12-month biopsies.

The association was in a relatively small number of patients studied, but it is potentially very interesting. It might allow us to diagnose interstitial fibrosis and tubular atrophy earlier in its course and intervene, with the goal of trying to maximize long-term outcomes and minimize the development of chronic changes over time. This is a small study and would need to be replicated in other centers, but it is an interesting approach to try to diagnose a problem early before it leads to irreversible chronic changes. Thank you.


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