Pineal Germinoma

Nandakumar Srinivasan, MD; Aneesh Pakala, MD; Chandana Mukkamalla, MD; Alok Oswal, MD


South Med J. 2010;103(10):1031-1037. 

In This Article


Pineal germinomas are rare but still can be seen in the adult population. Most of these patients present with hypothalamic pituitary axis dysfunction, including the symptoms of diabetes insipidus, hypogonadism, and cranial nerve involvement. Calcified pineal gland on a routine CT should raise the suspicion for pineal germinoma. In suspected cases, starting the work up with MRI, tumor markers, and CSF studies could be useful. If the above diagnostic studies are inconclusive, a stereotactic biopsy of the tumor for histopathology confirmation should be undertaken.


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