Adverse Effects of Proton Pump Inhibitor Drugs: Clues and Conclusions

Denis M. McCarthy


Curr Opin Gastroenterol. 2010;26(6):624-631. 

In This Article


PPIs enjoy an enviable record of safety, but like many drugs that experience a huge increase, particularly in long-term users, after initial marketing, subtle side-effects with low incidences but considerable clinical importance may gradually surface. These ADRs are often relevant only to small numbers of cases or cause only minor problems, but nevertheless they demand widespread education of providers as to their occurrence and management. The true importance of these kinds of events can only be estimated from careful prospective and, when possible, randomized, studies designed solely to measure safety, with minimal confounding. The effects of PPIs now demand such studies, especially addressing the ADRs already associated with their use.