Allergic Contact Dermatitis from Vitamin E: The Experience at Mayo Clinic Arizona, 1987 to 2007

Alison K. Adams; Suzanne M. Connolly


Dermatitis. 2010;21(4):199-202. 

In This Article


This study was approved by the Mayo Clinic institutional review board. Patch-test data from June 1987 through December 2007 were reviewed. Patients with a positive patch-test reaction to α-tocopherol were noted, and charts were reviewed for additional information, including site of dermatitis and relevance of the reaction. Patients who were patch-tested more than once during this period were counted as only one patient; a positive reaction on any of a patient's numerous patch tests was counted as a positive reaction.

Because of changes in the patch test of allergen sources during the study period, patients tested from 1987 through 1999 were tested with α-tocopherol at various concentrations in petrolatum. Patients who were patch-tested from 2000 through 2005 were tested with α-tocopherol acetate 10% in petrolatum; patients who were tested after 2005 were tested with α-tocopherol 100%. Statistical values were calculated with a two-tailed chi-square test. All statistical analysis was performed with SAS software (SAS Institute Inc., Cary, NC).


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