Leflunomide: Useful in the Treatment of Complex CMV?

Ron Shapiro, MD


October 07, 2010

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Hi, my name is Ron Shapiro. I am a transplant surgeon at the University of Pittsburgh. Today I want to talk with you about a really interesting paper on the use of leflunomide to treat refractory CMV infection.[1] Leflunomide is marketed as Arava for rheumatoid arthritis, and there has been some exploration, particularly from the University of Chicago group with Jim Williams, on its utility in treating BK virus. But this paper focuses on the utility in treating refractory CMV with leflunomide. In 17 patients, more than 80% of the patients were able to clear the viremia, and long-term sustained remissions occurred in over half of the patients. This study from the Cleveland Clinic is extremely interesting and bears further investigation with respect to the utility of leflunomide in patients with refractory CMV. Thank you.


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