Chronic Pruritus in the Absence of Specific Skin Disease: An Update on Pathophysiology, Diagnosis, and Therapy

Nicoletta Cassano; Gianpaolo Tessari; Gino A. Vena; Giampiero Girolomoni


Am J Clin Dermatol. 2010;11(6):399-411. 

In This Article


Pruritus is a very common and sometimes disabling symptom. Pruritus not associated with skin disorders or specific skin changes may be a symptom indicating the presence of an important disease. The diagnostic approach to patients with chronic itch may be complex and require multi-disciplinary interactions. New studies are shedding light on the complex mechanisms that induce chronic itch, and are revealing that multiple mediators may be involved in complex interactive pathways. The management of chronic severe itch is difficult and to be successful may require combination therapy for prolonged time periods.


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