The Sarcoid-lymphoma Syndrome

Trishna Goswami; Shahzad Siddique; Phillip Cohen; Bruce D. Cheson


Clin Lymphoma Myeloma. 2010;10(4):241-247. 

In This Article

Abstract and Introduction


Whether a relationship exists between sarcoidosis and lymphoma is controversial. We present 4 patients diagnosed with sarcoidosis either during or after the treatment of lymphoma, review the data surrounding the entity known as "sarcoid-lymphoma syndrome" and discuss the diagnostic pitfalls it can present. As both entities are fluorine-18 fluorodeoxyglucose avid, histologic verification and clinical acumen are needed to avoid misdiagnosis before initiating therapy.


The association between lymphoma and sarcoidosis was first suggested by Bichel and Brincker in the 1960s.[1] Since then, additional descriptions of this possible connection have been published[2,3] but without providing a better understanding of this relationship. We report 4 additional cases of "sarcoidosis-lymphoma syndrome" (SLS), including its occurrence in 2 sisters, and review the published literature.


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