Metoclopramide in the Treatment of Diabetic Gastroparesis

Allen Lee; Braden Kuo


Expert Rev Endocrinol Metab. 2010;5(5):653-662. 

In This Article

Adverse Effects

Dopamine-containing neurons are found in the substantia nigra, ventral tegmental area and hypothalamic nucleus. Nigrostriatal pathways with initiation, regulation and in the control of movements represent 80% of dopamine-containing neurons in the brain.[56,57] Dopamine-containing neurons from the hypothalamus projecting to the pituitary gland form the tuberoinfundibular pathway and act to suppress prolactin excretion.[58]

Most of the side effects from metoclopramide result from its ability to easily cross the blood–brain barrier and are observed in up to 30% of patients.[59,60] Drowsiness, fatigue and lethargy are reported by 10% of patients. Metoclopramide can also worsen underlying depression. Blockade of central D2 receptors may cause extrapyramidal reactions as well as hyperprolactinemia.


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