Oral Propranolol for Hemangiomas of Infancy

Marcia L. Buck, Pharm.D., FCCP, FPPAG


Pediatr Pharm. 2010;16(8) 

In This Article

Drug Interactions

Administration of pentobarbital, phenobarbital, phenytoin, or rifampin may increase the rate of propranolol metabolism and reduce serum concentrations, potentially decreasing the effectiveness of treatment. Concomitant use of calcium channel blockers, chlorpromazine, cimetidine, ciprofloxacin, diphenhydramine, flecainide, fluconazole, haloperidol, hydralazine, isoniazid, propylthiouracil, quinidine, ritonavir, selective serotonin receptor agonists (triptans), selective serotonin reuptake inhibitors (SSRIs), teniposide, terbinafine, theophylline, tricyclic antidepressants, and zileuton with propranolol may increase serum propranolol concentrations and increase the risk for toxicity.[2,3]

Propranolol should be administered with caution in patients receiving other antidiabetic, antiarrhythmic or blood pressure-regulating drugs. It may reduce the effectiveness of sympathomimetics in the management of patients with asthma. Concurrent use of propranolol may increase serum concentrations of diazepam or warfarin. It may reduce concentrations of lovastatin and pravastatin. Propranolol should not be given with ergot derivatives or monoamine oxidase inhibitors.[2,3]


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