Oxygen in Acute and Chronic Wound Healing

S. Schreml; R.M. Szeimies; L. Prantl; S. Karrer; M. Landthaler; P. Babilas


The British Journal of Dermatology. 2010;163(2):257-268. 

In This Article


Oxygen is well known to be required for wound healing. The Km for enzymes involved in bacterial killing, collagen synthesis, angiogenesis and epithelialization requires pO2 levels in wound tissue ranging from 25 to 100 mmHg.[9,23,37] Therefore, restricted oxygenation, as common in chronic wounds, impairs the healing process. Several studies have demonstrated that enhancing wound tissue oxygenation improves wound healing and reduces bacterial colonization. Further research should establish LLI as a new, promising tool for wound oximetry. This will probably enhance our understanding of the pathophysiology of chronic wound healing and of oxygen delivery and metabolism in the different healing zones of chronic wounds. Of special interest is monitoring the wound oxygenation under different therapeutic regimens to enable the well-founded selection of a suitable and efficient therapeutic modality for the individual patient. This will contribute to cost-effectiveness and hopefully will improve the quality of life of the affected patients.