Insights into Neurogenesis and Aging: Potential Therapy for Degenerative Disease?

Robert A Marr; Rosanne M Thomas; Daniel A Peterson


Future Neurology. 2010;5(4):527-541. 

In This Article

Future Perspective

There will be a pressing need for new therapies to address the age-related increase in neurological disease as we approach the estimated threshold in the year 2050 when 20% of the population will be older than 65 years of age. The combination of cell-mediated and gene therapies will likely play a central role in new therapies and the technical approaches to deliver cells and vectors to the brain are largely already in hand. Progress is largely limited by insufficient knowledge of critical regulatory signals and the way in which these act in concert to guide cell fate. It is likely that progress will be incremental as we acquire adequate knowledge concerning the necessary spatial and temporal concentration at which regulatory signals should be presented, either individually or in combination, to promote repair. However, once this degree of understanding is achieved, the development of successful therapies may proceed rapidly.


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