Treating Acne Vulgaris: Systemic, Local and Combination Therapy

Laura J Savage; Alison M Layton


Expert Rev Clin Pharmacol. 2010;13(4):563-580. 

In This Article

Azelaic Acid

Azelaic acid is available as a 20% cream for acne.[38,39] It has effects on comedogenesis by partially normalizing the disturbed terminal differentiation of keratinocytes in the follicular infundibulum.[40] A direct anti-inflammatory effect has been demonstrated[41] and it has been used successfully to treat postinflammatory hyperpigmentation resulting from deep-seated nodular inflammatory lesions. However, it is ineffective at suppressing sebum production and the previously reported impact of azelaic acid on the function and population density of P.acnes has recently been challenged.[42,43] Azelaic acid cream is a generally well-tolerated preparation that can cause cutaneous irritation, but this is usually less severe than with BPO or topical retinoids.


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