Treating Acne Vulgaris: Systemic, Local and Combination Therapy

Laura J Savage; Alison M Layton


Expert Rev Clin Pharmacol. 2010;13(4):563-580. 

In This Article

Systemic Therapy

Moderate-to-severe acne, or mild-to-moderate acne associated with scarring, significant psychosocial disability or failure to respond to topical therapies will require systemic therapy. This should be combined with topical therapy principally directed against the microcomedo, which is integral to the development of both inflammatory and noninflammatory lesions. Table 1 summarizes the impact of oral therapies on the etiological factors involved in the pathogenesis of acne vulgaris.


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