Treating Acne Vulgaris: Systemic, Local and Combination Therapy

Laura J Savage; Alison M Layton


Expert Rev Clin Pharmacol. 2010;13(4):563-580. 

In This Article


Topical nicotinamide is available as a 4% gel to be used twice daily and has anti-inflammatory actions. Double-blind studies have shown it to be more effective than the vehicle alone in older patients with acne, although considerable improvement was noted with the placebo.[62] It has been demonstrated to be as effective as 1% clindamycin gel,[63] and has the benefit over antimicrobials of not inducing P. acnes resistance, which may be of interest for patients requiring long-term maintenance therapy.[64,65]


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