Epinephrine and its Use in Anaphylaxis: Current Issues

Keith J. Simons; F. Estelle R. Simons

Disclosures

Curr Opin Allergy Clin Immunol. 2010;10(4):354-361. 

In This Article

Conclusion

Epinephrine, a century-old drug with multiple beneficial pharmacologic effects, remains the medication of first choice for the treatment of anaphylaxis. For ethical reasons, it is not possible to conduct randomized placebo-controlled trials of epinephrine in anaphylaxis; however, continued efforts are needed towards improving the evidence base for epinephrine injection in this potentially fatal disease.

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