PPI Dosing and Negative Consequences

Jamaluddin Moloo, MD, MPH

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These results remind us that high-dose PPIs might not provide additional benefit relative to lower-dose PPIs for patients with bleeding peptic ulcers and that high-dose PPI use among other patient populations could have negative consequences for bone health and C. difficile infections. An editorialist notes that more than 113 million prescriptions are written each year for PPIs and that they account for more than $13 billion in sales in the U.S. PPIs have clear clinical indications; however, they are overprescribed and likely have unintended negative consequences.

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