Protein Kinase C-β Gene Variants, Pathway Activation, and Enzastaurin Activity in Lung Cancer

Sang-Haak Lee; Tingan Chen; Jun Zhou; Jennifer Hofmann; Gerold Bepler

Disclosures

Clin Lung Cancer. 2010;11(3) 

In This Article

Conclusion

Apparently PKCβ2 does not possess sequence alterations that lead to enzastaurin hypersensitivity. The phosphorylation inhibition of PKCβ2, GSK3β, S6RP, Akt, and FKHR may constitute a useful pharmacodynamic parameter for in vivo target inhibition by enzastaurin.

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