Vertebral Artery Aneurysms and Cervical Arteriovenous Fistulae in Patients with Neurofibromatosis 1

Guillermo Higa; John P. Pacanowski Jr; David T. Jeck; Kaoru R. Goshima; Luis R. León Jr


Vascular. 2010;18(3):166-177. 

In This Article


The association between NF1 and VA aneurysms and AVF is rare. It is most often seen in the fourth or fifth decade of life. Two-thirds to three-quarters of these patients are females, and most report symptoms on presentation. The left VA is the most often afflicted. Multiple therapeutic methods exist, with most reports describing minimally invasive techniques for their management, associated with favorable outcomes. The presence of a cervical bruit in patients with NF1 who present with neurologic signs and symptoms on neck auscultation should prompt further vascular imaging. Awareness of the coexistence between NF1 and vascular disorders is crucial to avoid diagnostic delays and/or unnecessary surgical interventions in this setting, which have the potential to have dire consequences.


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