We provide novel data regarding how the timing of anticoagulation relates to mortality for patients with acute PE. Delayed anticoagulation in our cohort was a risk factor associated with increased mortality. Further investigations are warranted to elucidate the influence of certain demographics and comorbidities, but we nevertheless advocate that quality improvement measures be considered to expedite management of acute PE.
This study was supported by the National Center for Research Resources, a component of the National Institutes of Health (NIH) [Grant 1 UL1 RR024150-01] and the NIH Roadmap for Medical Research. The Center for Translation Science Activities at Mayo Clinic has NIH funding.
aPTT = activated partial thromboplastin time; CAD = coronary artery disease; CHF = congestive heart failure; DVT = deep vein thrombosis; IQR = interquartile range; LMWH = low-molecular-weight heparin; OR = odds ratio; PE = pulmonary embolism; SBP = systolic BP; VTE = venous thromboembolism
Dr Smith: contributed to collecting and analyzing the data.
Dr Geske: contributed to collecting and analyzing the data.
Dr Maguire: contributed to collecting and analyzing the data.
Mr Zane: contributed to collecting and analyzing the data.
Dr Carter: contributed to providing statistical support.
Dr Morgenthaler: contributed to providing review, guidance, and manuscript preparation.
The authors have reported to CHEST that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Role of sponsors
The contents of this article are solely the responsibility of the authors and do not necessarily represent the official view of National Center for Research Resources or NIH. Information on the National Center for Research Resources is available at https://www.ncrr.nih.gov/. Information on Reengineering the Clinical Research Enterprise can be obtained from https://nihroadmap.nih.gov/clinicalresearch/.
CHEST. 2010;137(6):1382-1390. © 2010 American College of Chest Physicians
Cite this: Early Anticoagulation is Associated with Reduced Mortality for Acute Pulmonary Embolism - Medscape - Jun 01, 2010.