Combination Therapy for Patients with Type 2 Diabetes: Repaglinide in Combination with Metformin

Robert G Moses


Expert Rev Endocrinol Metab. 2010;5(3):331-342. 

In This Article


In T2DM, optimal transition from monotherapy to combination therapy is essential to maintain glycemic control and minimize disease progression. Early combination therapy is recommended by current clinical guidelines in order to address both insulin resistance and deficiency in insulin secretion.[4,5] Combination therapy offers a number of advantages related to decreased incidence of adverse events, improved compliance and economic benefits. In addition, FDC medications have demonstrated improved compliance.[83]

Repaglinide and metformin target two different pathophysiological mechanisms underlying T2DM. Combination therapy with repaglinide plus metformin in the form of a single tablet has proven in several clinical studies to be a safe and effective therapeutic option for patients with T2DM with inadequate glycemic control. In addition, single-tablet combination therapy offers enhanced convenience in terms of dosing and patient adherence.


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