Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

GJ Manetti and SC Honig


Int J Impot Res. 2010;22(3):159-170. 

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Cryproterone Acetate

Cryproterone acetate is an active antiandrogen with progestin effects. It has been studied as hormone deprivation for prostate cancer. It has profound effects on libido, energy and decrease in hematocrit. Multiple studies[66–72] have been performed with combination cryproterone acetate and TE or TU. Doses ranging from 25 to 100 mg per day have suppressed spermatogenesis, but side effects have precluded subsequent studies. It has been postulated that antiandrogens may work well to suppress the effects of residual intratesticular testosterone not suppressed by other means.[38]


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