Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

GJ Manetti and SC Honig


Int J Impot Res. 2010;22(3):159-170. 

In This Article

Selective Androgen Receptor Modulators

Selective androgen receptor modulators or SARMs mimic the central and peripheral androgenic and anabolic effects of testosterone and are being trialed for treatment of prostate disease. Although steroidal SARMs, such as MENT, did not effectively maintain sperm suppression, recent animal models suggest that nonsteroidal SARMs may hold promise. In rat models, SARM c-6 was found to induce significant suppression of spermatogenesis.[97] A study on rats showed that a structurally modified SARM, (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide (S-23), combined with estradiol benzoate was an effective and reversible regimen for suppressing spermatogenesis in male rats.[98] These oral, synthetic nonsteroidal molecules have the potential to mimic steroids and suppress gonadotropin without unwanted side effects. The animal studies serve as interesting models for testing in humans as either primary or adjunctive therapy. Although these compounds appear to have an interesting mechanism of action, there have not been any clinical trials with these agents to date.


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