Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

GJ Manetti and SC Honig

Disclosures

Int J Impot Res. 2010;22(3):159-170. 

In This Article

Dienogest

Dienogest is a progestin with a lower degree of antiandrogenic and estrogenic activities. Preliminary data suggest that it can suppress gonadotropins without adverse side effects.[80] A study was conducted in rats using a combination of dienogest and TU monthly injection that showed 100% contraceptive efficacy and complete arrest of spermatogenesis. These data were based on findings of lack of sperm in the rat epididymis and suppression of spermatogenesis in testis tissue. No negative effects of lipid profiles were seen.[81] However, there is minimal data available on sperm suppression in humans and further investigation is needed.

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