The Effect of Estrogen on Appetite

Disclosures

Medscape General Medicine. 1998;1(3) 

In This Article

Tables

Table 1. Direct Controls of Meal Size

Anatomic Origin Stimulus Feedback Signal Route To Brain Stimulus Exerts Control in Humans Sex Differences in Stimulus Control Documented in Rats
Oropharynx Flavor + Cranial nerves Yes No
I,V,VII,IX,X ? ?
Stomach Volume - Cranial nerve X, Splanchnic nerve ? ?
- Gastric releasing peptide (GRP) Yes Yes
- Neuromedin B ? No
Intestine Volume - Cranial nerve X ? ?
Chemical - Cholecystokinin X Yes Yes
- Neurotensin ? ?
- Apolipoprotein A-IV ? ?
- Enterostatin ? ?
Pancreas Chemical - Glucagon (X) Yes Yes
- Insulin ? ?
- Amylin ? ?
- Somatostatin ? ?

+ = positive feedback signal (increases meal size); - = negative feedback signal (contributes to termination of meals); ? = data insufficient.

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