Keeping the Rhythm: hERG and Beyond in Cardiovascular Safety Pharmacology

Clemens Möller


Expert Rev Clin Pharmacol. 2010;3(3):321-329. 

In This Article

Established Assays for Testing the Cardiac Liabilities of Compounds

For cardiac safety assessment in drug development, a number of test systems have an established role in the pharmaceutical industry. These mainly include in vitro hERG channel testing (by the gold-standard patch clamp electrophysiology or other methods), in vitro tests on the other cardiac ion channels (described earlier), in vivo small-animal telemetry ECG, and, particularly as follow-up studies, more elaborated preparations and assays, such as studies in isolated Purkinje fibers, the perfused ventricular wedge or isolated (Langendorff) heart.[29–33]