Non-infectious Granulomatous Diseases of the Skin and their Associated Systemic Diseases: An Evidence-based Update to Important Clinical Questions

Elena Balestreire Hawryluk; Leonid Izikson; Joseph C. English III

Disclosures

Am J Clin Dermatol. 2010;11(3):171-181. 

In This Article

8. Conclusion

Non-infectious granulomatous diseases of the skin encompass a wide range of cutaneous and systemic manifestations. Several clinical questions were reviewed with the best available evidence-based data. Generalizations that can be made from our investigation are the following: (i) atypical GA in elderly patients should be evaluated with age-appropriate malignancy screening tests; (ii) NL patients should be screened for impaired glucose metabolism and diabetic-associated NL patients need monitoring for ocular and renal disease; (iii) accelerated rheumatoid nodulosis is not only caused by methotrexate but also etanercept, infliximab, and azathioprine; (iv) NXG is more commonly associated with MGUS and not myeloma but monitoring for malignant transformation of the MGUS is prudent; (v) although IGD and PNGD have been confused both clinically and histologically, routine screening for autoimmunity, malignancy, and medications should be initiated if either entity is suggested on histologic evaluation; (iv) all patients diagnosed with cutaneous sarcoidosis require screening for systemic involvement and dermatologists treating patients with sarcoidosis should be attentive to possible malignancy development; and (vii) MCD is in temporal discordance with associated gastrointestinal involvement.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....