What is the Optimal Therapy for Crohn's Disease: Step-up or Top-down?

Ming Valerie Lin; Wojciech Blonski; Gary R Lichtenstein


Expert Rev Gastroenterol Hepatol. 2010;4(2):167-180. 

In This Article

Five-year View

Current management recommendations for patients with CD are evolving. The focus of treatment will switch from maintaining clinical remission to complete mucosal healing, with halting the progression of the disease as the end point. Research is ongoing in the search for evidence for the benefit of early combination therapy. Reversal of the pyramids (the top-down approach) may be the future treatment direction and it will need to be guided by better definite timing and candidates, which may include an individual's genetic and serologic profiles.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: