In this heterogeneous sample of patients acutely admitted to hospital for symptoms of psychosis, the quetiapine group was associated with the most beneficial outcome in terms of reduction of the PANSS total score; the PANSS positive subscale score; the PANSS general psychopathology subscale score; the CGI-S score; and in increasing the GAF-F score. There were no substantial differences among the SGAs regarding tolerability outcomes.
ClinicalTrials.gov ID; URL: https://www.clinicaltrials.gov/: NCT00932529
The authors thank research nurses Ingvild Helle and Marianne Langeland at the Research Department, Division of Psychiatry, Haukeland University Hospital for their contributions. We also wish to thank the Division of Psychiatry, Haukeland University Hospital for financial support, and the Clinical Departments for enthusiasm and cooperation.
EJ drafted the manuscript and collected the data. RK and HAJ helped drafting the manuscript and participated in the data collection. TWL helped drafting the manuscript, provided statistical analyses and made substantial contributions to the analysis and interpretations of the data. All authors read and approved the final manuscript.
Funding of the project was initiated by the Research Council of Norway, followed by Haukeland University Hospital, Division of Psychiatry. The supporters had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review or approval of the manuscript.
EJ has received honoraria for lectures given in meetings arranged by Bristol-Myers Squibb, Eli Lilly, and AstraZeneca, and for a contribution to an information brochure by Eli Lilly.
BMC Psychiatry. 2010;10:26 © 2010 BioMed Central, Ltd.
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Cite this: Effectiveness of Second-generation Antipsychotics: A Naturalistic, Randomized Comparison of Olanzapine, Quetiapine, Risperidone, and Ziprasidone - Medscape - Apr 01, 2010.