Diagnosis and Management of Acute Liver Failure

Anne M. Larson


Curr Opin Gastroenterol. 2010;26(3):214-221. 

In This Article


When damage to the hepatic parenchyma is so severe that the liver is no longer able to meet the metabolic requirements of the body, the syndrome of ALF develops. The outcome is characterized by coagulopathy, hepatic encephalopathy, often associated with cerebral edema, hemodynamic changes, electrolyte disturbance, and renal failure. The exact relationship between hepatic injury and the syndrome of ALF is multifactorial, but our knowledge of the pathophysiology is limited by the lack of an adequate animal model of the disease.[3•]