Since probiotics contain live microorganisms, concurrent administration of antibiotics could kill a large number of the organisms, reducing the efficacy of the Lactobacillus and Bifidobacterium species. Patients should be instructed to separate administration of antibiotics from these bacteria-derived probiotics by at least two hours.[58,72] Similarly, S. boulardii might interact with antifungals, reducing the efficacy of this probiotic. According to the manufacturer, Florastor, which contains S. boulardii, should not be taken with any oral systemic antifungal products. Probiotics should also be used cautiously in patients taking immunosuppressants, such as cyclosporine, tacrolimus, azathioprine, and chemotherapeutic agents, since probiotics could cause an infection or pathogenic colonization in immunocompromised patients.[58,72,73]
Am J Health Syst Pharm. 2010;67(6):449-458. © 2010 American Society of Health-System Pharmacists
Cite this: Probiotics - Medscape - Mar 15, 2010.