Acitretin + EHK = PG: Toe Web Pyogenic Granuloma in a Man with Total Body Epidermolytic Hyperkeratosis on Acitretin – Report of A Unique Occurrence

Anik Amin; Tor Shwayder

Disclosures

Dermatology Nursing. 2009;21(6):345-347. 

In This Article

Abstract and Introduction

Abstract

A patient with total body epidermolytic hyperkeratosis who was successfully prescribed acitretin with the occurrence of a pyogenic granuloma is described in this case report.

Introduction

Epidermolytic hyperkeratosis (EHK), also known as bullous congenital ichthyosiform erythroderma, is a rare autosomal dominant disease of the ichthyosis family with a prevalence of 1 in 300,000 people (Shwayder, 1999). Individuals affected with EHK have describable symptoms from birth. Babies suffering from EHK have a very weak top layer of skin which blisters easily. Scaling occurs due to hyperkeratosis, in which excess keratin is produced and causes a thickening of the skin. Those affected with EHK may also have incidents of ectropion, palmoplantar keratoderma, and frequent skin infections (Steele, Shea, & Petronic-Rosic, 2007). However, pyogenic granuloma is not one of the known associations.

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