Meta-analysis: The Effects of Proton Pump Inhibitors on Cardiovascular Events and Mortality in Patients Receiving Clopidogrel

C. S. Kwok; Y. K. Loke


Aliment Pharmacol Ther. 2010;31(8):810-823. 

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In conclusion, the findings of this meta-analysis suggest that there is conflicting and inconsistent evidence on the impact of the clopidogrel PPI interaction on CV outcomes and certainly no evidence of any effect on overall mortality. Clinicians should carefully weigh up the real dangers of an increase in gastrointestinal haemorrhage events[13] before routinely avoiding the use of PPIs in patients taking clopidogrel.