From the results of our study, it can be concluded that melatonin could be used in the treatment of GERD either alone or in combination with omeprazole. The combination therapy of both melatonin and omeprazole is preferable as melatonin accelerates the healing effect of omeprazole and therefore shortens the duration of treatment and minimizes its side effects.
LES: lower esophageal sphincter; EC: enterochromaffin cells; NOS: Nitric Oxide Synthase.
The authors declare that they have no competing interests.
The manuscript has been seen and approved by all authors. TSK & AAM write the paper. TSK & AE designed research. TSK, AAM, AE & AMA performed research. TSK & AMA analyzed data.
The authors thanks all sample donors for their contribution to this work. The authors are grateful to Prof Dr Nabiel Gad El-hak "prof. of surgery" and all members in the motility unit, gastroenterology center, Mansoura, Egypt.
This paper has been linguistically revised by Dr Ahmad Hassan Ali, Lecturer of English Linguistics, Port Said Education Faculty, Department of English and proof reader of Suez Canal University, Port Said Branch, Graduate of USC, L.A., California, USA. ESP instructor, course designer and proof reader, Chief translator of Mansoura University ESPRC from 1990 till 2006.
BMC Gastroenterol. 2010;10:7 © 2010 Kandil et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cite this: The Potential Therapeutic Effect of Melatonin in Gastro-esophageal Reflux Disease - Medscape - Jan 18, 2010.