The Potential Therapeutic Effect of Melatonin in Gastro-esophageal Reflux Disease

Tharwat S Kandil; Amany A Mousa; Ahmed A El-Gendy; Amr M Abbas

Disclosures

BMC Gastroenterol. 2010;10:7 

In This Article

Results

Table 1 illustrates that pretreated Patients with GERD showed heartburn, epigastric pain, and significant decrease in LES pressure, residual pressure, relaxation percentage, pH, serum gastrin and mean melatonin level and a significant increase in relaxation duration and basal acid output (BAO) relative to control group.

Table 2 illustrates that treatment with melatonin for 4 and 8 weeks leads to marked improvement of GERD symptoms regarding heartburn and epigastric pain. There was also a significant increase in the tone of the LES in the form of increased LES pressure, a significant increase in the residual pressure, a significant decrease in the relaxation duration, a significant increase in the relaxation percentage, a significant increase in the pH with a significant decrease in BAO, and a significant increase in serum gastrin and mean melatonin levels relative to pretreated patients.

Table 3 illustrates that treatment with omeprazole for 4 and 8 weeks leads to marked improvement of GERD symptoms regarding heartburn and epigastric pain. There was also a non-significant change in the tone of the LES, a non-significant change in the residual pressure, relaxation duration, relaxation percentage, a significant increase in the pH with a significant decrease in BAO, a significant increase in serum gastrin and a non - significant increase in the melatonin level.

Table 4 illustrates that treatment with melatonin and omeprazole for 4 and 8 weeks leads to marked improvement of GERD symptoms regarding heartburn and epigastric pain. A significant increase in the tone of the LES in the form of increased LES pressure also noted. In addition, there is a significant increase in the residual pressure, a significant decrease in the relaxation duration, a significant increase in the relaxation percentage, a significant increase in the pH with a significant decreased in BAO and a significant increase in serum gastrin and melatonin levels.

Table 5 illustrates that treatment with melatonin alone or combined with omeprazole (Group II & IV) leads to a significant increase in the tone of the LES in the form of increased LES pressure. Also, there is a significant increase in the residual pressure, a significant decrease in the relaxation duration, a significant increase in the relaxation percentage compared with patients treated with omeprazole alone (group III), while patients treated with omeprazole alone or combined with melatonin (group III & IV) showed a significant increase in PH and serum gastrin level with a significant decrease in BAO than melatonin alone (group II)

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