Genetic Variability of Surfactant Protein-B and Respiratory Distress Syndrome: Clinical Implications

, Departments of Cellular and Molecular Physiology and Pediatrics; , Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pa.

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Determining the genetic basis of RDS can only be achieved through the cooperation and collaboration of individuals with expertise in a variety of disciplines, ranging from academic medicine and biostatistics to molecular biology and genetics. For example, an astute physician can distinguish among different clinical entities of the same disease; a basic scientist can identify the molecular cause and understand the underlying molecular mechanisms of each disease entity; an epidemiologist can appropriately design a study involving human subjects; and a statistical geneticist can correctly analyze data obtained. Thus, a multidisciplinary approach is required to understand the factors and the mechanisms involved in each RDS disease subgroup and to identify the best points for therapeutic intervention.


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