Unusual Clinical Presentations of Gout

Tony C. Ning; Robert T. Keenan


Curr Opin Rheumatol. 2010;22(2):181 

In This Article

Gout and the Respiratory System

When patients present with hoarseness, shortness of breath, stridor, dysphagia, or odynophagia, the differential diagnosis can be long. The usual culprits included infectious etiologies, neoplasms, and even rheumatological diseases such as Wegener's granulomatosis or relapsing polychondritis. The literature has described the role of gout involvement with the larynx.[62,63] In this series, a 72-year-old woman with a history of gout was described. The patient presented with a complaint of increased hoarseness. Endoscopic biopsy revealed a mass on the true vocal cord that was consistent with gout-crystal deposits. Treatment in this series ranged from endoscopic removal of the tophi, to an acute tracheostomy to relieve airway obstruction. Another report from China had examined the relationship with gout and lung injury.[64] Examination of this series of patients revealed urate crystals isolated from the spittle and the pleural fluid.


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