Unusual Clinical Presentations of Gout

Tony C. Ning; Robert T. Keenan


Curr Opin Rheumatol. 2010;22(2):181 

In This Article

Gout in Conjunction with Tumor

In addition to crystals depositing in unusual sites and mimicking tumors, it can be associated with them too. Tophi have been seen in conjunction with soft-tissue tumors. A recent report[56] described a 76-year-old man had presented to the hospital for a rapidly increasing tophi at the second and the third metacarpophalangeal joints. The patient had the tophi resected and pathological examination revealed not only the presence of gout crystals, but also a high-grade primary-fibrous histiocytoma (Fig. 4). In a case reported from Belgium, a 47-year-old man without any significant past history presented with swelling over the right index finger. On the basis of imaging and the vascularity of the mass, it was suspicious for a giant-cell tumor. Pathological examination revealed not only the giant-cell tumor, but also chalky, white deposits of negatively birefringent needle-shaped crystals.[57]

Figure 4.

This is the mass resected from the patients finger
On the left is the malignant histiocytoma, whereas on the right is the gouty tophus. This is taken from: Carnero S, Teran P, and Trillo E. Malignantfibrous histiocytoma arising in a gouty tophus at the second metacarpophalangeal joint. J Plast Reconstr Aesthet Surg 2006; 59:776. Figure 4


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