Low Levels of 25-hydroxyvitamin D in the Pediatric Populations: Prevalence and Clinical Outcomes

Michal L Melamed; Juhi Kumar


Pediatr Health. 2010;4(1):89-97. 

In This Article

Vitamin D & Bone Mineral Density

Low vitamin D levels have been associated with low bone mass, and therapy with vitamin D leads to higher growth velocity. In a study of 85 pediatric patients with primary or secondary osteoporosis, 21% had 25(OH)D levels below 20 ng/ml. In that study there was also a strong correlation between parathyroid hormone levels and 25(OH)D levels suggesting a physiologic impact to the low 25(OH)D levels.[22] Lack of sun exposure because of veiling in mothers is also associated with low bone mass in their children at adolescence.[48] A recent study showed that treatment of nutritional vitamin D deficiency with a 300,000 IU vitamin D3 injection in 40 children revealed a higher growth velocity standard deviation score after therapy compared with normal controls.[49] The children who were treated also showed a lowering of alkaline phosphatase and parathyroid hormone levels and increases in insulin growth factor-I levels. A study in 78 children and adolescents (10–18 years) on long-term therapy with anticonvulsants found similar increases in bone mineral density after a year of 400 IU/day or 2000 IU/day of vitamin D.[50]


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.