Morphine and PTSD Risk in Injured Combat Veterans

Peter Roy-Byrne, MD

Disclosures

Journal Watch 

In This Article

Abstract and Introduction

Abstract

Early use of morphine seems to protect against the later development of the disorder.

Introduction

An improved understanding of the pathophysiology of post-traumatic stress disorder has prompted researchers to explore the use of medication (e.g., beta blockers) for the secondary prevention of PTSD in traumatized and injured individuals.

These investigators used administrative data to examine whether morphine given during resuscitation or trauma care to injured U.S. military personnel affects the subsequent development of PTSD. Medical encounter forms and clinical records concerning 696 injured soldiers without serious traumatic brain injury were linked with assessments for PTSD made at military or private treatment facilities. These assessments occurred from 1 to 24 months after the injury; 243 soldiers received new PTSD diagnoses.

After controlling for injury severity, amputation, mild traumatic brain injury, and Glasgow Coma Scale score, the researchers found that receipt of morphine protected against the development of PTSD. Depending on the model used, odds ratios ranged from 0.49 to 0.67. The effects were not dependent on morphine dose.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....