Expanding the Time Frame for the Administration of Lytic Therapy in Ischemic Stroke

Charles R. Wira, III, MD


February 01, 2010

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  1. del Zoppo GJ, Saver JL, Jauch EC, Adams HP, on behalf of the American Heart Association Stroke Council. AHA/ASA Science Advisory. Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator. Stroke. 2009;40:2945. Available at Accessed January 27, 2010.

  2. Werner H, Kaste M, Bluhmki E, et al, for the ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 359:1317-1329. Available at Accessed January 28, 2010.


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