Nosocomial Outbreak of Novel Arenavirus Infection, Southern Africa

Janusz T. Paweska; Nivesh H. Sewlall; Thomas G. Ksiazek; Lucille H. Blumberg; Martin J. Hale; W. Ian Lipkin; Jacqueline Weyer; Stuart T. Nichol; Pierre E. Rollin; Laura K. McMullan; Christopher D. Paddock; Thomas Briese; Joy Mnyaluza; Thu-Ha Dinh; Victor Mukonka; Pamela Ching; Adriano Duse; Guy Richards; Gillian de Jong; Cheryl Cohen; Bridget Ikalafeng; Charles Mugero; Chika Asomugha; Mirriam M. Malotle; Dorothy M. Nteo; Eunice Misiani; Robert Swanepoel; Sherif R. Zaki

Disclosures

Emerging Infectious Diseases. 2009;15(10) 

In This Article

Abstract and Introduction

Abstract

A nosocomial outbreak of disease involving 5 patients, 4 of whom died, occurred in South Africa during September–October 2008. The first patient had been transferred from Zambia to South Africa for medical management. Three cases involved secondary spread of infection from the first patient, and 1 was a tertiary infection. A novel arenavirus was identified. The source of the first patient's infection remains undetermined.

Introduction

Arenaviruses associated with rodents are known to cause fatal hemorrhagic fevers in humans in South America and West Africa. We describe a nosocomial outbreak of infection with a novel arenavirus involving 5 patients, 4 of whom died, which occurred in South Africa in September–October 2008. The first patient was transferred from Zambia to South Africa for medical management. The source of her infection remains undetermined. Three cases involved secondary spread of infection from the first patient, and 1 tertiary infection occurred.

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