The Emerging Role of DNA Vaccines

W. Michael McDonnell, MD, Western Washington Medical Group, and Frederick K. Askari, MD, PhD, University of Michigan.

In This Article


There are no DNA vaccines on the market, nor even any published data showing efficacy in humans. Most human DNA vaccine trials are early in Phase I toxicity studies, although several trials have already progressed to Phase II. While these early studies have only just begun to provide suggestions regarding vaccine efficacy, the concepts brought forth by DNA vaccines have dramatically changed the way many investigators in the basic sciences are approaching their work.


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