Role of Omega-3 Fatty Acids in Maternal, Fetal, Infant and Child Wellbeing

Ellen Mozurkewich; Deborah R Berman; Julie Chilimigras


Expert Rev of Obstet Gynecol. 2010;5(1):125-138. 

In This Article

Low-risk Pregnancies

Szajewska, Horvath, and Koletzko also recently published a systematic review assessing the effect of LC-PUFA supplementation on low-risk pregnancies.[47] This meta-analysis, which combined six randomized, controlled trials, including 1278 participants, found a significant 1.57-day prolongation of pregnancy in these low-risk women. Similarly, Makrides' Cochrane review found a smaller prolongation of gestation among low-risk participants (2.23 days) than among high-risk women (8.5 days).[45] One large, multicenter, randomized, controlled trial has been published subsequent to the search dates of the three systematic reviews cited previously. This study, carried out as part of the Danish National Birth Cohort study, invited pregnant women to participate based on low self-reported dietary fish consumption and assigned those taking part to five different doses of fish oil, ranging from 0.1 to 2.8 mg, flax oil, placebo or no supplementation.[36] No difference in gestational length was seen between groups. The study investigator observed that this negative finding may be due to the fact that only a minority of participants took their assigned capsules through pregnancy and up to delivery.


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