Lung Cancer in Women: The Differences in Epidemiology, Biology and Treatment Outcomes

Maria Patricia Rivera

Disclosures

Expert Rev Resp Med. 2009;3(6):627-634. 

In This Article

Human Papillomavirus Infection

It has been reported that human papillomavirus (HPV) infection may induce the antiapoptotic effect of IL-6, thus promoting lung carcinogenesis.[47] HPV DNA using PCR and in situ hybridization was detected in the tumors of 49% of women with lung cancer who also had a history of high-grade cervical intraepithelial neoplasia.[48] In a study by Cheng et al., Taiwanese women with lung cancer were shown to have evidence of HPV-16/18 infection, and an association with lung cancer was seen in women and not in men.[49] The association of lung cancer with HPV infection is controversial, however, as others have not found this link.[50,51] An analysis of 32 squamous cell carcinomas and 15 cervical cancers using in situ hybridization and PCR was negative for HPV in the lung cancer cases, while 12 out of the 15 cervical cases were positive.[51]

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