Emergency Treatment Options for Pediatric Traumatic Brain Injury

J Exo; C Smith; R Smith; MJ Bell

Disclosures

Pediatr Health. 2009;3(6):533-541. 

In This Article

Conclusion & Future Perspective

In summary, children with TBI have significant chances of mortality and severe disability. Current neurocritical care therapies are directed toward normalizing physiological parameters in a step-wise manner, with maintenance of normal systemic function, treatment of mechanical disturbances, application of mild hyperventilation, administration of hyperosmolar therapies and induction of coma through use of barbiturates being the currently recognized agents. Experimental use of hypothermia has great promise for periods of intracranial hypertension and may be of utility as a neuroprotectant when applied early after injury. We believe that future research to improve neurological outcome will focus on optimal neurocritical care thresholds (interstitial brain oxygen concentrations, microdialysis measurements of stress metabolites or other parameters), improved nutritional support, an understanding of targeted therapies for intracranial hypertension and a greater understanding of the role of surgery for refractory medical cases. Development of novel therapies is urgently needed to provide further breakthroughs in treatment for these unfortunate children.

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