Rheumatic Manifestations of Endocrine Diseases

Joseph A. Markenson


Curr Opin Rheumatol. 2010;22(1):64-71. 

In This Article

Sjogren's Syndrome

Prevalence of thyroid disease runs from a low of 10% to a high of 70%; however, this may be related to the demographics of Sjogren's disease which usually affects older women. In one study hypothyroidism was 14% with thyrotoxicosis being 1.8%.[26] Symptoms of Sjogren's disease such as conjunctivitis sicca and xerostomia have been reported in up to 32% of patients with autoimmune thyroiditis.[27] In a large study of 479 patients with Sjogren's syndrome the frequency of Hashimoto's thyroiditis (6.26%) was found to be higher than in the normal population (1–2%); however, this increased frequency was not seen for Graves's disease. It was also recorded that presence of Graves's disease and Hashimoto's thyroiditis could appear either before or after the occurrence of Sjogren's syndrome making it difficult to ascertain if primary Sjogrens's syndrome was a predisposing factor for the development of autoimmune thyroiditis.[28]


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